Negative regulation of TORC1 signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of TORC1 signaling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB2, PIK3IP1, and DLGAP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of TORC1 signaling activity versus LMNB2 in HNSC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LMNB2 →	-0.707	-0.156	.003	<.001	3	5
GBM	PIK3IP1 →	+0.440	+0.143	.004	.001	3	4
GBM	DLGAP5 →	-0.884	-0.193	.004	.003	3	4
GBM	SURF1 →	+0.374	+0.243	<.001	<.001	3	4
HNSC	CDT1 →	-0.785	-0.118	<.001	.007	2	5
LSCC	CDCA2 →	-0.670	-0.147	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904262 vs LMNB2 — HNSC

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