Negative regulation of TORC1 signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of TORC1 signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD9, ZC3H7A, and LOXL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of TORC1 signaling activity versus NEDD9 in BLOOD_Myeloma (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEDD9 →	+2.395	+0.090	.002	.003	3	5
KIDNEY	ZC3H7A →	+0.612	+0.261	<.001	<.001	3	5
STOMACH	LOXL2 →	-4.640	-0.270	.002	.009	3	4
OVARY	SMPDL3B →	-1.980	-0.163	.001	.003	2	5
OVARY	FLYWCH1 →	+1.266	+0.221	.002	.004	3	4
BLOOD_Leukemia	NUBP2 →	+0.380	+0.095	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904262 vs NEDD9 — BLOOD_Myeloma

Explore this scatter interactively →