Positive regulation of membrane depolarization

Across TCGA patient cohorts, RNA activity of the Positive regulation of membrane depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP1B1, TRIM2_S428, and PDHA1_S232, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of membrane depolarization activity versus AP1B1 in CCRCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AP1B1 →	+0.157	+0.061	<.001	<.001	3	6
LSCC	TRIM2_S428 →	+0.756	+0.051	<.001	<.001	3	5
LUAD	PDHA1_S232 →	-0.927	-0.052	<.001	.001	3	5
BRCA	AP2A1 →	+0.138	+0.028	.001	<.001	3	5
UCEC	SVIL →	+0.423	+0.089	.007	.001	3	4
UCEC	SYNPO →	+0.452	+0.087	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904181 vs AP1B1 — CCRCC

Explore this scatter interactively →