Positive regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVCH1, CYP4Z1, and C1QL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OVCH1 grouped by Positive regulation of membrane depolarization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OVCH1 →	-0.158	-0.165	.002	.002	3	5
LUNG_NSCLC_LUSC	CYP4Z1 →	+0.170	+0.210	<.001	.002	3	4
BLOOD_Lymphoma	C1QL3 →	+0.510	+0.191	.001	.009	3	4
BONE	BTBD9 →	-0.258	-0.144	.007	.009	3	4
KIDNEY	PSMA6 →	-0.294	-0.121	.002	.002	3	4
LIVER	TSC22D1 →	-0.185	-0.174	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OVCH1 by Positive regulation of membrane depolarization activity — PANCREAS

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