Positive regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2E1, ACP7, and NPPB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2E1 grouped by Positive regulation of membrane depolarization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYP2E1 →	+0.180	+0.151	.004	.002	3	4
LIVER	ACP7 →	-0.366	-0.241	.005	<.001	3	4
SOFT_TISSUE	NPPB →	-0.306	-0.421	.006	.006	3	3
BREAST	TMEM116 →	+0.318	+0.142	.002	.006	3	3
KIDNEY	IL1RAPL1 →	+0.163	+0.303	<.001	.001	3	3
KIDNEY	NKX2-5 →	+0.290	+0.292	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2E1 by Positive regulation of membrane depolarization activity — LARGE_INTESTINE

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