Negative regulation of membrane depolarization

Across TCGA cell cohorts, RNA activity of the Negative regulation of membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTD2, PIGP, and UTP15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane depolarization activity versus DTD2 in PANCREAS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DTD2 →	+1.184	+0.316	<.001	<.001	3	5
OESOPHAGUS	PIGP →	+1.041	+0.340	.003	.008	2	5
LUNG_SCLC	UTP15 →	+0.743	+0.200	.001	.005	2	5
LUNG_NSCLC_LUSC	SLC19A3 →	+0.176	+0.240	.002	.001	3	4
LUNG_NSCLC_LUSC	HS3ST5 →	+0.092	+0.240	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SCP2 →	+0.951	+0.315	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904180 vs DTD2 — PANCREAS

Explore this scatter interactively →