Negative regulation of adipose tissue development

Across TCGA cell cohorts, RNA activity of the Negative regulation of adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf43, E2F2, and DDX6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adipose tissue development activity versus C12orf43 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf43 →	+0.398	+0.119	.003	.001	3	5
LUNG_SCLC	E2F2 →	+0.795	+0.081	.004	.006	2	6
BREAST	DDX6 →	+0.445	+0.125	.002	.006	3	4
OESOPHAGUS	CNTLN →	+1.422	+0.166	.002	.002	3	4
BLOOD_Leukemia	ARID1A →	+0.509	+0.070	.004	.005	3	4
BLOOD_Leukemia	UBR7 →	+0.584	+0.090	.008	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904178 vs C12orf43 — LARGE_INTESTINE

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