Axonemal central apparatus assembly

Across TCGA patient cohorts, RNA activity of the Axonemal central apparatus assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPEF1, CFAP91, and RSPH9, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal central apparatus assembly activity versus SPEF1 in UCEC (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPEF1 →	+2.201	+0.138	<.001	<.001	3	26
SCLC	CFAP91 →	+1.908	+0.688	<.001	<.001	3	24
SCLC	RSPH9 →	+1.180	+0.692	.001	.003	3	23
SCLC	DPCD →	+1.033	+0.817	<.001	<.001	3	22
UCEC	OSCP1 →	+0.976	+0.118	<.001	<.001	3	19
UCEC	B9D2 →	+0.697	+0.093	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904158 vs SPEF1 — UCEC

Explore this scatter interactively →