Axonemal central apparatus assembly

Across TCGA cell cohorts, RNA activity of the Axonemal central apparatus assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP91, CFAP206, and C15orf39, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal central apparatus assembly activity versus CFAP91 in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CFAP91 →	+1.318	+0.209	<.001	<.001	3	10
LUNG_SCLC	CFAP206 →	+0.636	+0.341	.003	.003	3	8
BLOOD_Leukemia	C15orf39 →	-0.404	-0.053	.005	.002	3	7
OVARY	DNAJB13 →	+1.579	+0.575	<.001	.009	3	6
BLOOD_Leukemia	EHHADH →	-0.880	-0.069	<.001	<.001	3	6
URINARY_TRACT	CCDC191 →	+0.845	+0.141	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904158 vs CFAP91 — LIVER

Explore this scatter interactively →