"Regulation of retrograde protein transport, ER to cytosol"

Across TCGA patient cohorts, RNA activity of the "Regulation of retrograde protein transport, ER to cytosol" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD36BP2, SLAMF1, and IGHM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde protein transport, ER to cytosol" activity versus ANKRD36BP2 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKRD36BP2 →	+1.042	+0.259	<.001	<.001	3	5
LSCC	SLAMF1 →	+0.773	+0.268	<.001	<.001	3	4
LSCC	IGHM →	+1.411	+0.253	<.001	<.001	3	4
HNSC	HLA-DOB →	+0.640	+0.199	.004	.001	3	4
GBM	ZNF330 →	-0.166	-0.132	.008	.005	3	4
GBM	FAM41C →	+0.073	+0.164	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904152 vs ANKRD36BP2 — LSCC

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