"Regulation of retrograde protein transport, ER to cytosol"

Across TCGA patient cohorts, RNA activity of the "Regulation of retrograde protein transport, ER to cytosol" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STT3B, SPCS2, and SGPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde protein transport, ER to cytosol" activity versus STT3B in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STT3B →	+0.644	+0.405	<.001	<.001	3	6
UCEC	SPCS2 →	+0.806	+0.275	<.001	<.001	3	6
BRCA	SGPP1 →	+0.649	+0.303	<.001	<.001	3	5
PDAC	TMEM19 →	+0.600	+0.189	<.001	.002	3	5
BRCA	UBE2J1 →	+0.630	+0.385	<.001	<.001	3	5
HNSC	SEC11C →	+0.901	+0.165	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904152 vs STT3B — BRCA

Explore this scatter interactively →