"Regulation of retrograde protein transport, ER to cytosol"

Across TCGA cell cohorts, RNA activity of the "Regulation of retrograde protein transport, ER to cytosol" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1B, PRKX, and TADA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of retrograde protein transport, ER to cytosol" activity versus TUBA1B in BLOOD_Leukemia (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TUBA1B →	-0.742	-0.641	<.001	<.001	3	4
BLOOD_Lymphoma	PRKX →	-1.507	-0.893	.003	.006	3	4
LARGE_INTESTINE	TADA1 →	-0.552	-0.542	.002	.008	2	5
LARGE_INTESTINE	TOP3A →	-0.640	-0.464	<.001	.003	3	4
LARGE_INTESTINE	BCAP31 →	+0.806	+0.551	.002	.009	3	4
BLOOD_Myeloma	CBX2 →	-1.186	-0.344	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904152 vs TUBA1B — BLOOD_Leukemia

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