Positive regulation of epithelial cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, P2RY8, and LYL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell apoptotic process activity versus ARHGAP9 in HNSC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP9 →	+0.681	+0.163	<.001	<.001	3	8
LSCC	P2RY8 →	+0.634	+0.172	.004	.005	3	8
BRCA	LYL1 →	+0.493	+0.175	.003	<.001	3	7
UCEC	FAM78A →	+0.704	+0.212	<.001	.005	3	7
HNSC	FLI1 →	+0.514	+0.177	<.001	<.001	3	7
OV	GRAP2 →	+0.561	+0.254	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904037 vs ARHGAP9 — HNSC

Explore this scatter interactively →