Positive regulation of epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIAS4, RAVER1, and CARM1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell apoptotic process activity versus PIAS4 in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PIAS4 →	+0.897	+0.104	<.001	<.001	3	11
BLOOD_Lymphoma	RAVER1 →	+1.204	+0.095	<.001	.001	3	11
BLOOD_Lymphoma	CARM1 →	+0.804	+0.108	<.001	<.001	3	10
BLOOD_Lymphoma	SMARCA4 →	+0.883	+0.102	<.001	<.001	2	11
BLOOD_Lymphoma	CHERP →	+0.729	+0.082	.001	.002	3	10
LARGE_INTESTINE	KHSRP →	+1.029	+0.150	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904037 vs PIAS4 — BLOOD_Lymphoma

Explore this scatter interactively →