Regulation of epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN7L1, EMSY, and KRT18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell apoptotic process activity versus ATXN7L1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATXN7L1 →	+0.865	+0.322	<.001	.002	3	5
LUNG_SCLC	EMSY →	+1.189	+0.382	<.001	<.001	3	5
BREAST	KRT18 →	+2.356	+0.300	<.001	<.001	3	5
BREAST	KRT8 →	+2.577	+0.317	<.001	<.001	3	5
BLOOD_Leukemia	TCF4 →	-1.446	-0.183	.003	<.001	3	5
BREAST	CACNA1D →	+1.848	+0.275	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904035 vs ATXN7L1 — UPPER_AERODIGESTIVE_TRACT

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