Positive regulation of cyclin-dependent protein kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of cyclin-dependent protein kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, EIF4B, and SEC24A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cyclin-dependent protein kinase activity activity versus RPL5 in CCRCC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL5 →	-0.249	-0.054	<.001	<.001	3	7
HNSC	EIF4B →	-0.207	-0.068	.001	.003	3	7
PDAC	SEC24A →	-0.174	-0.035	.009	.006	3	6
LUAD	TRIM2 →	+0.488	+0.038	.006	.001	3	6
HNSC	MAPRE3 →	+0.409	+0.053	.001	.004	2	7
GBM	API5_S464 →	-0.380	-0.071	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904031 vs RPL5 — CCRCC

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