Positive regulation of cyclin-dependent protein kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of cyclin-dependent protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH2, CYP2D6, and SPRY2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYTH2 grouped by Positive regulation of cyclin-dependent protein kinase activity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYTH2 →	-0.592	-1.211	.002	.002	3	4
LUNG_SCLC	CYP2D6 →	-0.963	-1.927	.002	.001	3	3
LUNG_SCLC	SPRY2 →	-2.340	-1.994	.001	<.001	3	3
LUNG_SCLC	DRC3 →	-1.361	-1.994	.001	<.001	3	3
SKIN	HDAC5 →	-0.766	-0.955	.002	.006	3	3
SKIN	CSRNP2 →	-0.552	-0.921	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYTH2 by Positive regulation of cyclin-dependent protein kinase activity activity — BLOOD_Leukemia

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