Positive regulation of cyclin-dependent protein kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of cyclin-dependent protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STOX1, CCNY, and ITGB1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cyclin-dependent protein kinase activity activity versus STOX1 in LIVER (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	STOX1 →	-1.429	-0.193	<.001	<.001	3	18
URINARY_TRACT	CCNY →	+1.207	+0.264	<.001	<.001	3	17
BONE	ITGB1 →	+2.085	+0.172	.001	.001	3	14
LUNG_NSCLC_LUAD	HPCAL1 →	+1.386	+0.147	.001	<.001	3	12
BONE	CD151 →	+1.419	+0.130	.006	.005	3	12
LIVER	ACTN1 →	+1.869	+0.145	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904031 vs STOX1 — LIVER

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