Regulation of collagen fibril organization

Across TCGA patient cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AEBP1, COL5A1, and RCN3, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of collagen fibril organization activity versus AEBP1 in KIRP (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	AEBP1 →	+2.454	+0.095	<.001	<.001	3	30
OV	COL5A1 →	+2.171	+0.100	<.001	<.001	3	30
HNSC	RCN3 →	+1.901	+0.118	<.001	<.001	3	30
TGCT	PCOLCE →	+2.258	+0.110	<.001	<.001	3	29
CHOL	MMP19 →	+1.238	+0.066	.001	<.001	3	29
ESCA	ISLR →	+2.410	+0.124	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904026 vs AEBP1 — KIRP

Explore this scatter interactively →