Regulation of collagen fibril organization

Across TCGA patient cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, RSU1, and TAGLN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of collagen fibril organization activity versus RCN3 in BRCA (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCN3 →	+0.639	+0.097	<.001	<.001	3	10
UCEC	RSU1 →	+0.511	+0.127	<.001	<.001	3	10
OV	TAGLN →	+0.989	+0.126	<.001	<.001	3	10
COAD	THBS2 →	+1.219	+0.072	<.001	<.001	3	10
UCEC	TPM1 →	+0.658	+0.108	<.001	<.001	3	10
UCEC	TPM2 →	+1.119	+0.121	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904026 vs RCN3 — BRCA

Explore this scatter interactively →