Regulation of collagen fibril organization

Across TCGA patient cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC16, NEK3, and NUDT15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of collagen fibril organization activity versus CDC16 in COAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDC16 →	+0.430	+0.229	<.001	.004	3	4
BRCA	NEK3 →	+0.628	+0.263	<.001	<.001	3	4
BRCA	NUDT15 →	+0.444	+0.196	.008	.008	3	4
BRCA	NAA16 →	+0.272	+0.174	.008	<.001	3	4
BRCA	SUCLA2-AS1 →	+0.337	+0.165	.001	.005	3	4
LUAD	RNU1-72P →	+0.975	+0.236	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904026 vs CDC16 — COAD

Explore this scatter interactively →