Regulation of collagen fibril organization

Across TCGA cell cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM54, TMEM35B, and TOX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM54 grouped by Regulation of collagen fibril organization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM54 →	-2.221	-1.349	<.001	<.001	3	4
CNS	TMEM35B →	-0.799	-1.069	.001	.002	3	4
SOFT_TISSUE	TOX2 →	-2.960	-1.372	.002	.005	3	3
SOFT_TISSUE	MYO1E →	-2.396	-1.415	.008	.004	3	3
SOFT_TISSUE	TIPARP →	-2.133	-1.209	.001	.002	3	3
SOFT_TISSUE	CLMN →	-1.937	-1.304	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM54 by Regulation of collagen fibril organization activity — SOFT_TISSUE

Explore this box plot interactively →