Regulation of collagen fibril organization

Across TCGA cell cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD23, GTF2F2, and CCDC120, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of collagen fibril organization activity versus ANKRD23 in OESOPHAGUS (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ANKRD23 →	-1.132	-0.247	.001	<.001	2	11
LARGE_INTESTINE	GTF2F2 →	+0.814	+0.279	<.001	<.001	3	10
BONE	CCDC120 →	-1.315	-0.291	<.001	<.001	3	10
STOMACH	HIP1R →	-1.093	-0.203	.003	<.001	3	10
BONE	ANKRD24 →	-1.511	-0.253	<.001	<.001	3	10
OVARY	TMC4 →	-2.506	-0.210	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904026 vs ANKRD23 — OESOPHAGUS

Explore this scatter interactively →