Regulation of collagen fibril organization

Across TCGA cell cohorts, RNA activity of the Regulation of collagen fibril organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARVELD3, ADAP1, and ABCG2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of collagen fibril organization activity versus MARVELD3 in BLOOD_Leukemia (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MARVELD3 →	-0.150	-1.332	.003	<.001	3	2
BLOOD_Leukemia	ADAP1 →	+3.453	+1.451	.003	<.001	3	1
BLOOD_Leukemia	ABCG2 →	-0.986	-1.385	.003	<.001	3	1
BLOOD_Leukemia	LRP3 →	+4.560	+1.399	<.001	<.001	3	1
BLOOD_Leukemia	LCN2 →	-2.180	-1.278	.001	<.001	3	1
BLOOD_Leukemia	IFNGR2 →	+1.423	+1.463	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904026 vs MARVELD3 — BLOOD_Leukemia

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