Epithelial cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN11, STS, and PREX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell apoptotic process activity versus CLDN11 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLDN11 →	+0.893	+0.184	.002	<.001	3	4
BRCA	STS →	+0.864	+0.239	<.001	.001	3	4
BRCA	PREX1 →	+1.431	+0.328	<.001	<.001	3	4
BRCA	KLF2 →	+0.966	+0.299	<.001	<.001	3	4
BRCA	ACVRL1 →	+0.624	+0.290	<.001	<.001	3	4
OV	SERPING1 →	+1.094	+0.202	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904019 vs CLDN11 — OV

Explore this scatter interactively →