Epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Epithelial cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, PAK1IP1, and OR2T10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Epithelial cell apoptotic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BCL2L1 →	-0.585	-0.141	.006	.002	3	4
LUNG_SCLC	PAK1IP1 →	+0.323	+0.187	.002	.001	3	4
LUNG_SCLC	OR2T10 →	-0.336	-0.215	<.001	.003	3	4
LUNG_NSCLC_LUSC	RPL3 →	-0.369	-0.265	.001	.003	3	4
LUNG_NSCLC_LUAD	CD40 →	-0.161	-0.182	.006	.004	2	4
LUNG_NSCLC_LUSC	SUFU →	-0.235	-0.246	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Epithelial cell apoptotic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →