Epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BPNT1, ATG4D, and DBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BPNT1 grouped by Epithelial cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BPNT1 →	+1.003	+1.155	<.001	.004	3	5
BREAST	ATG4D →	+0.639	+0.781	.001	.004	3	5
BONE	DBP →	+1.507	+1.230	.006	.001	3	4
BREAST	PAK4 →	+1.449	+1.049	<.001	<.001	3	4
BONE	SPTBN4 →	+1.577	+1.219	.004	.001	3	4
BONE	DNAJC7 →	-0.685	-1.370	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BPNT1 by Epithelial cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →