Positive regulation of vasculature development

Across TCGA patient cohorts, RNA activity of the Positive regulation of vasculature development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMTN, STAB1, and TAGLN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vasculature development activity versus SMTN in OV (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMTN →	+1.011	+0.072	<.001	<.001	3	10
GBM	STAB1 →	+0.471	+0.054	<.001	<.001	3	10
CCRCC	TAGLN →	+1.024	+0.037	<.001	<.001	3	10
UCEC	TPM1 →	+0.676	+0.053	<.001	<.001	3	10
UCEC	TPM2 →	+1.041	+0.049	<.001	<.001	3	10
GBM	COL6A3 →	+0.994	+0.054	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904018 vs SMTN — OV

Explore this scatter interactively →