Positive regulation of vasculature development

Across TCGA cell cohorts, RNA activity of the Positive regulation of vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT2D, OR2A1, and SDC4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KMT2D grouped by Positive regulation of vasculature development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KMT2D →	+0.780	+1.120	<.001	.003	3	3
LIVER	OR2A1 →	-0.331	-1.378	.005	.003	3	3
CNS	SDC4 →	-1.298	-0.756	<.001	.002	3	3
CNS	NCEH1 →	-1.689	-0.872	<.001	.001	3	3
CNS	AXL →	-2.288	-0.791	<.001	.001	3	3
CNS	DRAP1 →	-0.870	-0.758	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KMT2D by Positive regulation of vasculature development activity — LIVER

Explore this box plot interactively →