Response to Thyroglobulin triiodothyronine

Across TCGA patient cohorts, RNA activity of the Response to Thyroglobulin triiodothyronine pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F5, ANKRD46, and COA7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to Thyroglobulin triiodothyronine activity versus E2F5 in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	E2F5 →	+0.457	+0.210	.001	.009	3	4
BRCA	ANKRD46 →	+0.506	+0.257	.003	.006	3	4
PDAC	COA7 →	+0.330	+0.686	.001	.004	3	3
LUAD	NDUFB9 →	+0.351	+0.343	.003	.003	3	3
LSCC	COX6C →	+0.480	+0.468	.001	.002	3	3
OV	AXL →	-0.792	-0.515	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904016 vs E2F5 — BRCA

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