Regulation of eating behavior

Across TCGA cell cohorts, RNA activity of the Regulation of eating behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MC4R, GHRL, and SLC24A4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MC4R grouped by Regulation of eating behavior-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MC4R →	-0.341	-1.786	.005	<.001	3	9
CNS	GHRL →	-0.248	-1.204	<.001	.001	3	8
CNS	SLC24A4 →	-0.234	-0.947	.008	.006	3	6
PANCREAS	GHSR →	-0.227	-1.319	.001	<.001	2	7
LARGE_INTESTINE	NPSR1 →	-0.261	-1.196	<.001	<.001	3	5
LUNG_SCLC	LITAF →	-0.375	-1.426	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MC4R by Regulation of eating behavior activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →