Regulation of eating behavior

Across TCGA cell cohorts, RNA activity of the Regulation of eating behavior pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT7, INTS4, and UTP18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KAT7 grouped by Regulation of eating behavior-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KAT7 →	+0.803	+1.262	<.001	.002	3	4
OESOPHAGUS	INTS4 →	+0.973	+1.302	<.001	<.001	3	4
PANCREAS	UTP18 →	+0.552	+1.178	.003	.001	2	5
BLOOD_Leukemia	MIGA2 →	-0.636	-1.320	.008	<.001	3	4
BLOOD_Myeloma	CCDC15 →	+1.024	+1.636	<.001	.003	3	4
URINARY_TRACT	NFU1 →	+0.801	+1.242	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KAT7 by Regulation of eating behavior activity — OESOPHAGUS

Explore this box plot interactively →