Negative regulation of microglial cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of microglial cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTBP2, RAB7B, and GSTM2P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTBP2 grouped by Negative regulation of microglial cell activation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CTBP2 →	-0.248	-1.446	.005	.003	3	2
OVARY	RAB7B →	+0.456	+1.754	.008	.002	3	2
LARGE_INTESTINE	GSTM2P1 →	-0.264	-1.777	.006	<.001	3	2
LUNG_NSCLC_LUAD	RGL2 →	-0.130	-1.818	.007	<.001	2	3
LUNG_NSCLC_LUAD	TVP23C-CDRT4 →	-0.133	-1.802	<.001	<.001	3	2
LUNG_SCLC	PHF13 →	-0.225	-2.193	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTBP2 by Negative regulation of microglial cell activation activity — OVARY

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