Negative regulation of microglial cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of microglial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, SWAP70, and NAXD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of microglial cell activation activity versus GSR in BLOOD_Leukemia (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSR →	+0.920	+0.725	<.001	.005	3	3
BREAST	SWAP70 →	+1.027	+1.757	.004	<.001	3	3
BREAST	NAXD →	-0.978	-1.661	.001	<.001	3	3
BLOOD_Lymphoma	LRIG3 →	-1.328	-1.155	.002	<.001	3	3
BLOOD_Lymphoma	TTYH2 →	-1.656	-1.179	.009	.005	3	3
BLOOD_Lymphoma	CENPC →	+1.205	+1.211	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903979 vs GSR — BLOOD_Leukemia

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