Regulation of microglial cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of microglial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB9, BCAP31, and MTRNR2L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASB9 grouped by Regulation of microglial cell activation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ASB9 →	+1.552	+1.406	.007	.004	3	4
LARGE_INTESTINE	BCAP31 →	+0.794	+1.047	.002	.001	2	4
LUNG_NSCLC_LUSC	MTRNR2L3 →	+0.044	+1.039	.001	.003	3	3
LUNG_SCLC	PLCB1 →	-2.593	-1.055	<.001	.005	2	4
BREAST	SLC19A2 →	-0.917	-0.778	.003	.008	1	5
BREAST	SEMA7A →	+1.665	+1.006	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASB9 by Regulation of microglial cell activation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →