Regulation of microglial cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of microglial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLOC1S6, SEPTIN2, and SCRN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microglial cell activation activity versus BLOC1S6 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BLOC1S6 →	+0.955	+1.186	.008	.002	3	4
LUNG_NSCLC_LUAD	SEPTIN2 →	+0.920	+1.352	.002	.001	3	4
LARGE_INTESTINE	SCRN1 →	+2.787	+1.289	.007	.009	3	4
URINARY_TRACT	MRC2 →	+4.225	+1.940	.009	.001	3	4
BONE	ASB1 →	+0.602	+1.527	<.001	.008	3	3
OVARY	CFAP61 →	-0.372	-1.338	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903978 vs BLOC1S6 — BLOOD_Lymphoma

Explore this scatter interactively →