Positive regulation of glial cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPI1, LST1, and ABI3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell migration activity versus SPI1 in SCLC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	SPI1 →	+1.515	+0.205	<.001	<.001	3	32
SCLC	LST1 →	+2.233	+0.213	<.001	<.001	3	31
SCLC	ABI3 →	+2.236	+0.198	<.001	<.001	3	30
SCLC	MS4A6A →	+2.054	+0.225	<.001	<.001	3	30
SCLC	LY86 →	+1.865	+0.223	<.001	<.001	3	30
SCLC	CD86 →	+2.638	+0.152	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903977 vs SPI1 — SCLC

Explore this scatter interactively →