Positive regulation of glial cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B, TRIM21, and DOCK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell migration activity versus TBC1D2B in UCEC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TBC1D2B →	+0.322	+0.067	<.001	.003	3	10
HNSC	TRIM21 →	+0.444	+0.066	<.001	<.001	3	10
OV	DOCK10 →	+0.361	+0.052	.001	<.001	3	10
COAD	ARHGEF6 →	+0.492	+0.075	<.001	<.001	3	10
LSCC	SASH3 →	+0.415	+0.079	<.001	<.001	3	9
LSCC	WDFY4 →	+0.344	+0.061	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903977 vs TBC1D2B — UCEC

Explore this scatter interactively →