Positive regulation of glial cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIAM1_S1407, TIAM1_S52, and ATG2A_S403, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell migration activity versus TIAM1_S1407 in UCEC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIAM1_S1407 →	+0.733	+0.818	.001	.002	2	5
GBM	TIAM1_S52 →	+0.793	+0.701	<.001	<.001	3	4
LUAD	ATG2A_S403 →	+0.650	+0.557	<.001	<.001	3	3
GBM	SRRM2_S1517 →	-0.665	-0.665	<.001	<.001	3	3
GBM	SRRM2_T848 →	-0.745	-1.015	<.001	<.001	3	3
UCEC	SYNPO_S263 →	+0.755	+0.576	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903977 vs TIAM1_S1407 — UCEC

Explore this scatter interactively →