Negative regulation of glial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXD4L6, GABARAP, and IRX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXD4L6 grouped by Negative regulation of glial cell migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FOXD4L6 →	-0.041	-0.654	.002	.007	3	4
LARGE_INTESTINE	GABARAP →	+0.861	+1.230	.001	.007	3	4
SOFT_TISSUE	IRX3 →	-3.163	-2.141	<.001	<.001	3	4
STOMACH	HIPK2 →	-2.374	-1.489	<.001	<.001	3	4
LUNG_SCLC	DUX4 →	+0.067	+1.289	.003	<.001	3	4
SKIN	FXYD5 →	-1.692	-1.455	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXD4L6 by Negative regulation of glial cell migration activity — BREAST

Explore this box plot interactively →