Regulation of glial cell migration

Across TCGA patient cohorts, RNA activity of the Regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR3122, CEP170, and MFSD10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell migration activity versus MIR3122 in GBM (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR3122 →	-1.176	-0.298	<.001	.002	3	4
LUAD	CEP170 →	-0.321	-0.720	.003	<.001	3	4
UCEC	MFSD10 →	-1.060	-0.552	.001	.004	3	4
GBM	TTK →	-0.969	-0.352	<.001	<.001	3	4
GBM	PIMREG →	-1.166	-0.288	<.001	<.001	3	4
UCEC	CIP2A →	-0.874	-0.488	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903975 vs MIR3122 — GBM

Explore this scatter interactively →