Regulation of glial cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT4B, SLC38A9, and NCR3LG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGAT4B grouped by Regulation of glial cell migration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MGAT4B →	+0.996	+1.575	.008	.002	3	4
LARGE_INTESTINE	SLC38A9 →	+0.617	+0.756	<.001	.005	3	4
LARGE_INTESTINE	NCR3LG1 →	-1.233	-0.946	<.001	.005	3	4
LARGE_INTESTINE	BIRC3 →	+1.420	+1.167	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZIC2 →	-1.261	-1.258	.006	.008	3	4
BLOOD_Lymphoma	SEPHS2 →	-1.189	-1.433	.003	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGAT4B by Regulation of glial cell migration activity — LIVER

Explore this box plot interactively →