Regulation of glial cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERS2, PSMD4, and PSMB4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell migration activity versus CERS2 in BREAST (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CERS2 →	+1.320	+0.290	<.001	<.001	3	7
LUNG_NSCLC_LUAD	PSMD4 →	+0.948	+0.280	.001	<.001	3	5
LUNG_NSCLC_LUAD	PSMB4 →	+0.979	+0.235	<.001	.002	3	4
BONE	SNAPIN →	+0.792	+0.215	.001	.001	3	4
BREAST	SPATA6 →	+0.724	+0.187	.002	.001	3	4
BREAST	VPS45 →	+0.755	+0.184	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903975 vs CERS2 — BREAST

Explore this scatter interactively →