Negative regulation of hepatocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of hepatocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3IL1, SLC25A15, and RFC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hepatocyte apoptotic process activity versus RAB3IL1 in GBM (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAB3IL1 →	-0.476	-0.213	<.001	<.001	3	5
GBM	SLC25A15 →	+0.367	+0.170	<.001	<.001	3	4
GBM	RFC3 →	+0.583	+0.211	<.001	<.001	3	4
BRCA	PTPN22 →	-0.592	-0.631	.002	.004	2	5
LUAD	KIF21A →	+0.559	+0.312	.001	<.001	2	5
GBM	CCDC34 →	+0.540	+0.278	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903944 vs RAB3IL1 — GBM

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