Negative regulation of hepatocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of hepatocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR, PARP4, and TMOD3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hepatocyte apoptotic process activity versus CFLAR in OESOPHAGUS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CFLAR →	+2.511	+0.209	<.001	<.001	3	14
STOMACH	PARP4 →	+0.820	+0.124	.003	.003	3	10
OVARY	TMOD3 →	+0.775	+0.125	.004	.008	3	10
OESOPHAGUS	ZBTB38 →	+1.446	+0.183	.002	.002	3	10
LUNG_SCLC	CASP8 →	+1.675	+0.082	<.001	.004	3	10
OVARY	CAB39 →	+0.896	+0.149	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903944 vs CFLAR — OESOPHAGUS

Explore this scatter interactively →