Regulation of hepatocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of hepatocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP5, KRT8, and KRT18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hepatocyte apoptotic process activity versus RAB11FIP5 in OVARY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RAB11FIP5 →	-1.145	-0.563	<.001	.001	3	4
LUNG_SCLC	KRT8 →	+5.233	+0.466	<.001	<.001	3	4
LARGE_INTESTINE	KRT18 →	+1.687	+0.144	.001	.003	3	4
LARGE_INTESTINE	PRRG2 →	+0.937	+0.133	.002	.008	2	5
BREAST	NHEJ1 →	-0.843	-0.134	.002	.007	2	4
BREAST	EIF4EBP1 →	-1.676	-0.144	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903943 vs RAB11FIP5 — OVARY

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