Regulation of TORC2 signaling

Across TCGA patient cohorts, RNA activity of the Regulation of TORC2 signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR646, ACSL3, and DEPTOR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of TORC2 signaling activity versus MIR646 in OV (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIR646 →	-0.666	-0.755	.002	.003	3	3
PDAC	ACSL3 →	+0.351	+0.832	.001	.001	3	3
PDAC	DEPTOR →	+0.387	+0.539	.004	.004	3	3
PDAC	CSDC2 →	-0.379	-0.702	.006	.001	2	4
PDAC	SNRNP40 →	+0.212	+0.662	.006	.004	3	3
CCRCC	MAF →	-0.345	-0.479	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903939 vs MIR646 — OV

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