Regulation of TORC2 signaling

Across TCGA cell cohorts, RNA activity of the Regulation of TORC2 signaling pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP1, FMNL3, and LPCAT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTNAP1 grouped by Regulation of TORC2 signaling-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CNTNAP1 →	-1.666	-1.206	.008	.003	3	6
BREAST	FMNL3 →	-0.887	-0.249	.006	.004	3	5
OVARY	LPCAT2 →	-1.826	-1.029	.001	.004	3	5
LIVER	FKTN →	-0.755	-1.439	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	ARSK →	-0.879	-1.871	.006	.002	3	5
UPPER_AERODIGESTIVE_TRACT	SLC39A14 →	-1.123	-1.469	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTNAP1 by Regulation of TORC2 signaling activity — KIDNEY

Explore this box plot interactively →