Regulation of TORC2 signaling

Across TCGA cell cohorts, RNA activity of the Regulation of TORC2 signaling pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBTPS2, ALG12, and TAX1BP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of TORC2 signaling activity versus MBTPS2 in LARGE_INTESTINE (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MBTPS2 →	-1.086	-0.339	.001	.003	3	4
BLOOD_Myeloma	ALG12 →	+1.088	+0.499	.004	<.001	3	4
BLOOD_Leukemia	TAX1BP3 →	+0.819	+0.299	.001	.004	3	4
BLOOD_Leukemia	CREG1 →	-1.539	-0.335	<.001	.001	3	4
BLOOD_Leukemia	ADAM15 →	-1.758	-0.304	.005	.009	3	3
LUNG_SCLC	ABHD10 →	+1.157	+0.771	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903939 vs MBTPS2 — LARGE_INTESTINE

Explore this scatter interactively →