Cellular response to sodium arsenite

Across TCGA cell cohorts, RNA activity of the Cellular response to sodium arsenite pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL22, LASP1, and APLP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL22 grouped by Cellular response to sodium arsenite-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLHL22 →	-0.122	-0.119	.005	.003	3	4
LUNG_SCLC	LASP1 →	-0.185	-0.200	.003	.001	3	4
CNS	APLP1 →	-0.303	-0.123	.005	.006	3	4
LUNG_SCLC	MAT1A →	+0.209	+0.120	.001	.008	3	4
LARGE_INTESTINE	E2F8 →	-0.138	-0.077	<.001	.002	3	4
OVARY	LRP11 →	+0.227	+0.082	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL22 by Cellular response to sodium arsenite activity — STOMACH

Explore this box plot interactively →